Alzheimer’s Strategic Fund: Neuroimmune Program

Sponsor Deadline: 

Aug 20, 2020

Letter of Intent Deadline: 

Aug 20, 2020

Sponsor: 

Alzheimer's Association

UI Contact: 

Alzheimer’s Disease AD Strategic Fund: Neuroimmune Program
AD Strategic Fund   https://www.braininstitute.pitt.edu/alzheimers-association-strategic-fun...
Find the RFA on Proposal Central  https://proposalcentral.com/GrantOpportunities.asp
LOI due August 20, 2020.

-  Cause(s) of the Disease: How and why do specific sets of neurons in select brain
structures become dysfunctional? Why is there selective vulnerability in specific
brain regions and not in others? What initiates these processes and are they cell
autonomous or non-cell autonomous in nature? What are key steps in the
cascade of events leading to neuronal cell death? How do genetic factors interact
with other factors to influence these processes?

-  Experimental Models of Disease: Considerable advances have been made in the
development of cellular and animal models for AD; however, these model
systems do not capture the full complexity of the human condition. This has been
problematic in applying these models to predict the success of specific
therapeutic interventions in individuals with AD. Are there novel technologies or
approaches that recapitulate the disease progression and/or pathogenesis to
support model applications?

-  Early and Accurate Detection and Diagnosis: What are the most sensitive,
specific and cost-effective diagnostic procedures? What are the most sensitive,
specific and cost-effective procedures for assessing change throughout the
course of the disease?

-  Treatment: What are the most effective and safe pharmacological treatment
strategies, behavioral management techniques, and combinations of therapies?

-  Tool development: What are key tools and/or resources that if developed will
benefit a broader range of scientific questions and/or studies? Tools and
resources developed through this funding would be made broadly available to the
scientific field.

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