Sponsor link www.arthritis.org/science
ProposalCentral link https://proposalcentral.com/grantopportunities.asp?GMID=137#

Opportunity full title: Characterizing Determinants of Response and Nonresponse to Current Rheumatoid Arthritis (RA) Therapeutic Agents: Request for Proposals on Refractory RA Research

This Request for Proposals (RFP) invites applications for characterization of the distinct mechanisms, biomarkers, and therapeutic targets that distinguish RA responders and non-responders to therapy. Research projects that propose the examination of the socio-economic determinants of therapeutic non-response are also of interest. The long-term goal of this AF research program is to improve the lives of RA patients for whom currently available therapies are ineffective. The funding for this initiative will be provided by the Arthritis Foundation’s Science Budget. 

Research proposals should focus on investigating determinants of treatment response and non-response in patients with Rheumatoid Arthritis (RA). Applicants should ensure that the definition of non-response to be used in the study is clearly articulated. Research studies using clinical samples and/or clinical data are strongly encouraged. Animal studies are not allowed. Proposed research may include, but is not limited to:

•  Identifying underlying biological mechanisms, including but not limited to immunologic, genetic, epigenetic, and/or biochemical;
•  Revealing novel therapeutic targets;
•  Addressing patients with well-controlled disease according to standard assessment tools, but still experiencing RA symptoms, including pain, that are reducing their quality of life; and/or
•  Uncovering social determinants of health and their association with lack of response to treatment.