CDC Understanding Polydrug Use Risk and Protective Factors, Patterns, and Trajectories to Prevent Drug Overdose
RFA-CE-22-011
Grants.gov  https://www.grants.gov/web/grants/view-opportunity.html?oppId=336247

Optional Letters of Intent are requested by January 7, 2022.
Eligible applicant organizations may submit more than one application to this NOFO, provided that each application is scientifically distinct. However, applicant institutions can submit only one application with the same contact PD/PI

This funding would support up to five applications for 3 years at up to $350,000 per award per year to conduct research to improve our understanding of risk and protective factors, patterns, and trajectories related to polydrug use, with a focus on polydrug combinations most likely to result in nonfatal overdose or death, such as combinations including synthetic opioids. Polydrug combinations of interest include the following,  Co-use of multiple opioids, knowingly or unknowingly (i.e., due to unknown adulterants)  Co-use of non-opioid drugs (particularly psychostimulants [e.g., methamphetamine], cocaine, and benzodiazepines) AND opioids, knowingly or unknowingly  Co-use of other combinations of drugs that may result in drug overdose Applicants shall focus on identifying risk and protective factors, AND patterns, AND trajectories of polydrug use for either 1) the general population OR 2) one or more of the following subpopulations of interest:  Persons who have experienced acute or chronic pain and used prescription opioids to manage their pain  Persons who use cannabis, either medically or non-medically.