In 2024, ALSF Crazy 8 Initiative will focus on Childhood Cancer Predisposition and Prevention. It is now estimated that at least 15-20% of children with cancer harbor a germline cancer predisposition gene.

Although currently about 100 cancer predisposition syndromes are known, there are clearly more syndromes and more genes to be discovered. There is a need to identify cancers in these individuals early to establish surveillance protocols for effective treatment. In addition, there is a need to develop effective approaches to prevent or delay tumor onset in children determined to be genetically at risk.

The focus of this award will be on multiple aspects of a single cancer predisposition syndrome, or on a broader area (e.g. surveillance) across a number of different syndromes. 

Read the announcement and details for this grant (pdf)