Targeted Evaluation of Ionizing Radiation Exposure (TEI-REX)
This Broad Agency Announcement (BAA) which sets forth research areas of interest to the Army Research Laboratory-Army Research Office (ARL-ARO) and the Intelligence Advanced Research Projects Activity (IARPA)
Proposals due: December 13, 2021 by 5:00 PM EDT
The Targeted Evaluation of Ionizing Radiation Exposure (TEI-REX) program seeks proposals for new methods of quantifying lower-dose (<0.75 Gray) ionizing radiation exposure to an organism, shifting away from methods which are dependent upon invasive sampling and more traditional DNA, RNA, and expression-based signatures. The objectives are to discover robust biomarkers associated with TEI-REX samples, develop methods for enabling the detection of these signatures, and develop computational models to interpret these signatures in relation to the exposure event. Ideally, these biomarkers will be conserved across organisms and/or sample types enabling improved extensibility. Realistically, the program recognizes the significant challenge this research objective represents and that initial steps likely will focus on a limited number of optimal model organisms and sample targets. Offerors are encouraged to describe how extensible their biomarker(s) may be to other samples or models but must focus on how they will apply their proposed research against the primary objectives of this program instead of theorizing towards an ideal objective.