Pre-applications due Jan. 3, 2024. Invited applicants must submit a full application due Jan. 10, 2024.

This funding concept supports research that addresses gaps in our knowledge of the underlying biology of CNS remyelination in MS, the factors or processes that modulate this process, and methods to measure remyelination. Additionally, research into neuroprotective mechanisms with the potential to prolong neuronal viability for remyelination is encouraged. The supported research is intended to lay the foundation for the next generation of therapeutic approaches. 

In addition, the concept supports the development or refinement of tools needed to support preclinical and clinical studies of remyelination and neuroprotection in MS, including in vitro and animal models that more closely reflect MS pathophysiology and clinical biomarkers with utility for measuring CNS myelination and neuroprotection. Applications proposing the testing of new or established biomarkers must include relevant components of analytical method validation to ensure that a test, tool, or instrument is adequate for its proposed context of use.

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