NIAID Adjuvant Comparison and Characterization
BAA-DAIT-75N93020R00022
Contract Opportunity Type: Solicitation (Original)
Original Date Offers Due: September 16, 2021 03:00 pm EDT
Beta.sam.gov   https://beta.sam.gov/opp/7ecb122e2b924d6aaa97cc76c2a3a8aa/view?utm_campaign=%2046833493&utm_content=&utm_medium=email&utm_source=govdelivery&utm_term=

The purpose of this Broad Agency Announcement (BAA) is to solicit proposals for a research program that includes the comparison of multiple adjuvants using various vaccine/antigen platforms. The comparative studies will establish immunological profiles ("immune fingerprints") of adjuvants that work through different mechanisms to evaluate strength, quality, breadth, and durability of responses using:
1.  "omics" technology platforms such as genomics, epigenomics, transcriptomics, RNAi screens, proteomics, metabolomics, lipidomics, and glycomics;
2.  T cell functional assays (e.g., cytotoxicity, cytokine production, epitope specificity); and
3.  B cell and antibody profiles to include assessment of isotype, avidity, epitope fine-specificity, and systems serology.