NSF Reproducible Cells and Organoids via Directed-Differentiation Encoding - preliminary

Sponsor Deadline: 

Feb 18, 2021

Letter of Intent Deadline: 

Feb 18, 2021

Sponsor: 

National Science Foundation

UI Contact: 

NSF Reproducible Cells and Organoids via Directed-Differentiation Encoding
21-532    https://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf21532

Preliminary Proposal (required) February 18, 2021.

The National Science Foundation (NSF) Divisions of Chemical, Bioengineering, Environmental and Transport Systems (CBET), Integrative and Organismal Systems (IOS), Molecular and Cellular Biosciences (MCB), and Civil, Mechanical, and Manufacturing Innovation (CMMI) seek proposals that elucidate mechanisms of, and develop strategies to, direct the differentiation of undifferentiated cells into mature, functional cells or organoids. Projects responsive to this solicitation must aim to establish a robustly validated and reproducible set of differentiation design rules, mechanistic models, real-time sensing, control, and quality assurance methods, and integrate them into a workable differentiation strategy. They must deepen our fundamental understanding of how cells develop and differentiate, providing insights into mechanisms, molecular machinery, dynamics, and cell-cell and cell-extracellular matrix (ECM) interactions, and use this understanding to manipulate cells purposefully. Investigators can choose any undifferentiated cell type from any animal species, including those that may be considered non-model organisms, as a starting point and choose any appropriate functional product (cell, organoid, etc.) with real-world relevance.

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