PCORI Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes, Cycle 1 2018 - LOI

Sponsor Deadline: 

Feb 13, 2018


PCORI Patient-Centered Outcomes Research Institute

UI Contact: 

PCORI Pragmatic Clinical Studies to Evaluate Patient-Centered Outcomes, Cycle 1 2018

Required Letter of Intent due Feb. 13, 2018.

Cycle 1 2018 PCORI PCS Priority Topics

  • Treatment of anxiety in children, adolescents, and young adults;
  • Compare the benefits and harms of pharmacologic, psychological, or combination treatments for treating different types of insomnia (sleep onset vs. sleep maintenance insomnia) on sleep and patient-centered outcomes including next-day function, mood, and quality of life;
  • Community-acquired pneumonia;
  • Studies of patients with non-muscle invasive bladder cancer (NMIBC) who failed first-line treatments;
  • Screening, Brief Intervention, and Referral to Treatment (SBIRT) for adolescent alcohol abuse;
  • Surgical options for hip fracture in the elderly;
  • Multicomponent interventions to reduce initiation of tobacco use and promote cessation of tobacco use among high-risk populations with known disparities;
  • Integration of mental and behavioral health services into the primary care of persons at risk for disparities in health care and outcomes;
  • Remote delivery approaches for treating depression with anxiety;
  • Treatment strategies for symptomatic osteoarthritis (OA), including joint replacement​;
  • Improving outcomes in mothers and babies at risk for disparities by comparing evidence-based models of perinatal care;
  • Treatment strategies to reduce non-traumatic lower extremity amputations in racial or ethnic minorities and low-income populations with diabetes;
  • Post-neonatal intensive care discharge support services for infants and their families or caregivers​;
  • Strategies to prevent dental caries in children in medically underserved areas;
  • Strategies to improve post-hospital discharge outcomes by integrating pharmacists into the care team;
  • Reducing suicide, suicidal behavior among adolescents​.