The PCORI Targeted PFAs seek proposals that answer these questions (below).
Required Letter of Intent due Oct. 5, 2021

-- Healthy Aging: Optimizing Physical and Mental Functioning Across the Aging Continuum -- Cycle 3 2021 
With the different phases of the aging continuum in mind, how can we achieve one or more of the following four goals? Maintaining function and independence; Facilitating chronic disease management; Supporting individuals with significant functional impairment; Reducing caregiving burden and improving quality of life.

--  Comparative Effectiveness of Multimodal Interventions to Prevent Osteoporotic Fractures -- Cycle 3 2021
What is the comparative effectiveness of multimodal treatment interventions (i.e., combination of pharmacologic and/or non-pharmacologic) on patient-centered outcomes in people with osteoporosis and a history of fractures? 

--  Comparative Effectiveness of Novel Pharmacologic and Evidence-Based Nonpharmacologic Treatments for Migraine Prevention -- Cycle 3 2021
What is the comparative effectiveness of novel pharmacologic and/or evidence-based nonpharmacologic treatments for the prevention of migraine headaches?