SENS Research Foundation Research Grant - LOI required

Sponsor Deadline: 

Feb 1, 2024

Letter of Intent Deadline: 

Feb 1, 2023


SENS Research Foundation

UI Contact: 

Sponsor link

Rolling deadline: If your LOI is approved, your full proposal will be due within 1 year of your LOI approval date.

SENS Research Foundation was founded to catalyze progress in the “damage-repair” approach for medical intervention in degenerative aging, and we will only fund proposals that clearly offer the potential to progress toward medical therapies using this approach. “Damage-repair” interventions are those that directly remove, repair, replace, or render harmless specific cellular and molecular “damage” in aging tissues.

By “damage,” we mean stable, structural, accumulating alterations to molecular and cellular structures over time, rather than unstable intermediates or reactive precursors:  for instance, advanced glycation endproducts rather than Schiff bases and Amadori products; established mutations rather than repairable DNA lesions; stable aggregates such as beta-amyloid oligomers and plaques rather than initial APP cleavage products.

We will not fund proposals aimed toward therapies that modulate metabolic pathways as their approach. This eliminates most interventions that could be achieved by small-molecule drugs, which inhibit or promote some targeted pathway of metabolism. Indeed, it rules out most medical therapies used in current clinical practice or in human clinical trials today.

Instead, a “damage-repair” proposal will clearly lead toward the direct removal or repair of some form of aging damage, which generally entails delivering some novel capacity that the organism does not intrinsically have as part of normal metabolism. MORE DETAIL AT LINK