Space Health Institute: Counteracting Bodily and Cellular Wear-and-Tear from Spaceflight


Translational Research Institute for Space Health (TRISH) at Baylor College of Medicine

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2022 TRISH Biomedical Research Advances for Space Health (BRASH)
NASA Human Exploration and Operations Mission Directorate

The solicitation is available online here and is composed of two phases.
Step-1 proposals are due January 26, 2022 by 5 p.m. EST.
Step-2 proposals from selected investigations will be due April 19, 2022 by 5 p.m. EST.

The Translational Research Institute for Space Health (TRISH) at Baylor College of Medicine, with consortium partners California Institute of Technology (Caltech) and Massachusetts Institute of Technology (MIT), announced today it is seeking scientific proposals for disruptive technologies, therapies, and/or approaches to protecting astronaut health through enhancing pre-existing internal cellular repair functions.

The NASA-funded Institute’s Biomedical Research Advances for Space Health (BRASH) solicitation invests in emerging science with potential to reduce risks to human health and performance during future Artemis missions and beyond. Deep space exploration comes with multiple physiological and psychological stressors for astronauts, including increased radiation exposure, gravity changes, isolation and confinement, and an omnipresent hostile/dangerous environment. These stressors negatively impact health, through tissue degradation, DNA damage, cell death, neurological changes, and more. The BRASH solicitation seeks ways to reduce multiple crew health risks while enhancing the body’s ability to control endogenous repair and maintenance processes to support optimal organ, tissue and cell function for astronauts.

“TRISH is committed to finding new approaches to increase endogenous repair. This is needed to safeguard health in the extremes of space, and has applications for Earth, through improvements to cellular repair, healing, or normal wear-and-tear that occurs with physical and mental challenges as well as aging,” said Dorit Donoviel, TRISH’s Executive Director.